PT - JOURNAL ARTICLE
AU - Owens, S M
AU - Hardwick, W C
AU - Blackall, D
TI - Phencyclidine pharmacokinetic scaling among species.
DP - 1987 Jul 01
TA - Journal of Pharmacology and Experimental Therapeutics
PG - 96--101
VI - 242
IP - 1
4099 - http://jpet.aspetjournals.org/content/242/1/96.short
4100 - http://jpet.aspetjournals.org/content/242/1/96.full
SO - J Pharmacol Exp Ther1987 Jul 01; 242
AB - Interspecies pharmacokinetic parameters (y) for phencyclidine [1-(1-phenylcyclohexyl)piperidine] were correlated with body weight (B) using linear regression and the allometric equation of the form y = aBx (which also may be written as the linear regression equation, log y = x log B + log a). The data were obtained from previously reported pharmacokinetic studies in mammals (i.e., humans, monkey, dog, rat and mouse) and new pharmacokinetic data for the pigeon. The animal body weights ranged from 32.5 to 77,000 g and included 6 animal species from 2 vertebrate classes. The pharmacokinetic parameters correlated with body weight were T1/2 (T1/2 = 126B0.32, r2 = 0.799), volume of distribution (V beta = 10B0.96, r2 = 0.966) and systemic clearance (CLs = 50B0.64, r2 = 0.891). In addition, clearance values were multiplied by the maximum lifespan potential (MLP) of each animal and correlated with body weight [CLs X MLP = (3.3 X 10(5))B1.0, r2 = 0.991]. This helped normalize for species differences in systemic clearance, which correlated with species longevity. These allometric equations should provide the information for scaling phencyclidine pharmacokinetic data among diverse species.