RT Journal Article
SR Electronic
T1 Effects of atropine upon various components mediating postprandial gastric acid secretion in dogs.
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 396
OP 399
VO 240
IS 2
A1 R G Pendleton
A1 R J Bendesky
A1 P G Cook
YR 1987
UL http://jpet.aspetjournals.org/content/240/2/396.abstract
AB Dose-response curves in chronic gastric fistula dogs were first obtained to chemical stimulants of the three accepted physiological excitatory components regulating postprandial gastric acid secretion. These were: 2-deoxy-D-glucose, a central vagal stimulant; gastrin, a hormone; and histamine, a paracrine factor. Using equiactive doses of each, a dose of atropine just maximal for suppressing all of the anatomical phases of food-induced acid secretion in vagally innervated pouch dogs was found to inhibit substantially the responses to all three of the above stimulants. The above results argue in favor of an interdependent model among the above factors for regulating postprandial gastric acid secretion in the dog.