PT  - JOURNAL ARTICLE
AU  - R G Pendleton
AU  - R J Bendesky
AU  - P G Cook
TI  - Effects of atropine upon various components mediating postprandial gastric acid secretion in dogs.
DP  - 1987 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 396--399
VI  - 240
IP  - 2
4099  - http://jpet.aspetjournals.org/content/240/2/396.short
4100  - http://jpet.aspetjournals.org/content/240/2/396.full
SO  - J Pharmacol Exp Ther1987 Feb 01; 240
AB  - Dose-response curves in chronic gastric fistula dogs were first obtained to chemical stimulants of the three accepted physiological excitatory components regulating postprandial gastric acid secretion. These were: 2-deoxy-D-glucose, a central vagal stimulant; gastrin, a hormone; and histamine, a paracrine factor. Using equiactive doses of each, a dose of atropine just maximal for suppressing all of the anatomical phases of food-induced acid secretion in vagally innervated pouch dogs was found to inhibit substantially the responses to all three of the above stimulants. The above results argue in favor of an interdependent model among the above factors for regulating postprandial gastric acid secretion in the dog.