PT  - JOURNAL ARTICLE
AU  - S. A. MATTHEWS
AU  - CLYDE BROOKS
TI  - ON THE ACTION OF MAGNESIUM SULPHATE
DP  - 1910 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 87--99
VI  - 2
IP  - 2
4099  - http://jpet.aspetjournals.org/content/2/2/87.short
4100  - http://jpet.aspetjournals.org/content/2/2/87.full
SO  - J Pharmacol Exp Ther1910 Oct 01; 2
AB  - 1. These experiments tend to confirm the curare-like action of magnesium sulphate, particularly as described by the French authors. 2. Magnesium sulphate in doses sufficient to give marked action upon the motor endings, produces little effect upon the respiratory centre; but in larger doses, it causes depression of the centre. When administered to the unanæsthetized dog, primary stimulation of the respiratory movements were observed. 3. The action of magnesium upon the heart is best explained as that of a depression of the cardiac nervous mechanism involving particularly the accelerators.