RT Journal Article
SR Electronic
T1 The sympathomimetic activity of N-isopropyloctopamine in vitro.
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 553
OP 558
VO 225
IS 3
A1 W G Anderson
YR 1983
UL http://jpet.aspetjournals.org/content/225/3/553.abstract
AB Isolated right and left guinea-pig atria, guinea-pig tracheae and rabbit aortic strips were used to define the sympathomimetic properties of N-isopropyloctopamine. This compound was a highly beta selective, direct-acting adrenergic agonist, approximately 200- and 440-fold less potent than isoproterenol in cardiac and smooth muscle, respectively. It was nearly a full agonist in both cardiac and smooth muscle without appreciable selectivity for either beta-1 or beta-2 receptors and had no demonstrable beta blocking activity. No alpha adrenergic activity was detectable within the concentration range tested. The chronotropic effect of N-isopropyloctopamine was very persistent and resistant to repeated washing of the tissues, which may reflect unusually firm binding to beta receptors.