TY - JOUR T1 - Anticholinergic potency of diphenhydramine (Benadryl) measured against bethanechol in the gastric fistula dog. JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 171 LP - 173 VL - 226 IS - 1 AU - B I Hirschowitz AU - E Molina Y1 - 1983/07/01 UR - http://jpet.aspetjournals.org/content/226/1/171.abstract N2 - We quantitated the gastric secretory anticholinergic effect of diphenhydramine (Benadryl) against graded doses of bethanechol, a cholinergic agonist, which was used to stimulate acid and pepsin secretion. Anticholinergic potency of diphenyhydramine was 10,000 times less than that reported for atropine and was 1,000 times less than the reported potency of diphenhydramine antagonism of histamine H-1 effects. ER -