PT  - JOURNAL ARTICLE
AU  - M W Lo
AU  - D J Effeney
AU  - S M Pond
AU  - B M Silber
AU  - S Riegelman
TI  - Lack of gastrointestinal metabolism of propranolol in dogs after portacaval transposition.
DP  - 1982 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 512--515
VI  - 221
IP  - 2
4099  - http://jpet.aspetjournals.org/content/221/2/512.short
4100  - http://jpet.aspetjournals.org/content/221/2/512.full
SO  - J Pharmacol Exp Ther1982 May 01; 221
AB  - We studied whether or not propranolol underwent presystemic metabolism in the gastrointestinal wall in five dogs. The dogs were studied before and four weeks after creation of a portacaval transposition. Before surgery, systemic bioavailability of the oral dose was 8 +/- 8% (mean +/- S.D.), whereas after transposition the bioavailability was 102 +/- 9%. The systemic plasma clearance increased from 766 +/- 192 to 976 +/- 280 ml/min. The terminal half life and apparent volume of distribution after transposition were not significantly different from those obtained preoperatively. Our results indicate that there is complete absorption but no metabolism of propranolol by the gastrointestinal wall.