PT  - JOURNAL ARTICLE
AU  - Braszko, J J
AU  - Bannon, M J
AU  - Bunney, B S
AU  - Roth, R H
TI  - Intrastriatal kainic acid: acute effects on electrophysiological and biochemical measures of nigrostriatal dopaminergic activity.
DP  - 1981 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 289--293
VI  - 216
IP  - 2
4099  - http://jpet.aspetjournals.org/content/216/2/289.short
4100  - http://jpet.aspetjournals.org/content/216/2/289.full
SO  - J Pharmacol Exp Ther1981 Feb 01; 216
AB  - The acute effects of intrastriatal kainic acid injection in nigrostriatal dopamine cell activity were assessed using electrophysiological and biochemical techniques. One hour after kainic acid injection, dopamine cell firing rates were significantly increased, as were striatal dopamine synthesis (dopa accumulation) and dopamine metabolism (3,4-dihydroxyphenylacetic acid levels). Twelve hours postkainic acid administration, cell firing rate had returned to control levels, as had dopa accumulation and DOPAC levels, but the number of dopamine cells firing had significantly decreased. Action potentials were elicited from the "silent" dopamine cells by iontophoretic application of gamma-aminobutyric acid but not glutamate. Conversely, 48 hr after kainic acid, the number of dopamine cells firing was significantly increased, as were 3,4-dihydroxyphenylacetic acid levels. Both cell firing rate and dopa accumulation, however, matched control values. The results are discussed in terms of the role of strionigral pathways in mediating the acute effects of kainic acid on the nigrostriatal dopaminergic system and are interpreted in light of the recently described phenomenon of presumed dopamine cell depolarization inactivation.