TY - JOUR T1 - Does histamine influence vasodilation caused by prolonged arterial occlusion or heavy exercise? JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 533 LP - 538 VL - 215 IS - 2 AU - A Daniel AU - C R Honig Y1 - 1980/11/01 UR - http://jpet.aspetjournals.org/content/215/2/533.abstract N2 - Vasodilation induced by prolonged arterial occlusion or fatiguing exercise is thought by some to be due, in part, to histamine. To test this hypothesis, we studied isolated canine gracilis muscles perfused at low, constant flow. Diphenhydramine and cimetidine, H1 and H2 receptor antagonists, respectively, were used in combination. Vasodilation induced by a supramaximal dose of histamine was abolished but vasodilation after occlusions thought capable of inducing ischemic injury was unchanged in magnitude or time course. Vasodilation during moderate or heavy exercise at constant flow was also unaffected. We conclude that reactive hyperemia and exercise vasodilation in skeletal muscle do not depend even in part on histamine. ER -