RT Journal Article
SR Electronic
T1 Effects of acetaldehyde upon mechanical properties of isolated rat papillary muscle.
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 219
OP 222
VO 214
IS 1
A1 Sakurai, T
A1 Bing, O H
A1 Huber, G
A1 Abelmann, W H
YR 1980
UL http://jpet.aspetjournals.org/content/214/1/219.abstract
AB The acute effects of acetaldehyde upon the performance of isolated rat papillary muscle were studied. At high concentrations (50 and 100 mg/100 ml), acetaldehyde demonstrated a negative inotropic effect and abbreviated relaxation time. Pretreatment with either propranolol or reserpine unmasked a direct negative inotropic effect of acetaldehyde at concentrations as low as 5 mg/100 ml. The shortening of relaxation was also blocked by propranolol and reserpine. These findings are compatible with both a direct myocardial depressant effect and an indirect beta-stimulatory effect of acetaldehyde. In the range of concentrations encountered clinically, however, acetaldehyde is not likely to have a significant acute effect upon cardiac muscle performance.