PT  - JOURNAL ARTICLE
AU  - Miller, D S
AU  - Shehata, A T
AU  - Lerner, J
TI  - HgCl2 inhibition of D-glucose transport in jejunal tissue from 2 day and 21 day chicks.
DP  - 1980 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 101--105
VI  - 214
IP  - 1
4099  - http://jpet.aspetjournals.org/content/214/1/101.short
4100  - http://jpet.aspetjournals.org/content/214/1/101.full
SO  - J Pharmacol Exp Ther1980 Jul 01; 214
AB  - Chick jejunal slices that were exposed to HgCl2 exhibited markedly reduced uptakes of D-glucose. The carrier-mediated (phloridzin inhibitable), but not diffusive, component of uptake was affected by Hg. Within each age group, I50 values (concentration of HgCl2 causing 50% inhibition of mediated transport) for slices (mucosal plus serosal exposure) and sacs (mucosal exposure only) were nearly identical; values for brush border membrane vesicles were slightly lower (increased sensitivity). For each preparation, I50 values for 2 day chicks were consistently lower than corresponding values for 21 day chicks. Taken together, these data indicate that the jejunal brush border membrane is a site of HgCl2 action and that membrane sites in tissue from 2 day chicks are more sensitive to Hg than similar sites in tissue from 21 day chicks.