PT  - JOURNAL ARTICLE
AU  - Thomsen, K
AU  - Olesen, O V
TI  - The effect of water deprivation on lithium clearance and lithium excretion fraction in lithium-polyuric rats.
DP  - 1979 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 327--329
VI  - 209
IP  - 3
4099  - http://jpet.aspetjournals.org/content/209/3/327.short
4100  - http://jpet.aspetjournals.org/content/209/3/327.full
SO  - J Pharmacol Exp Ther1979 Jun 01; 209
AB  - The effect of water deprivation on lithium clearance was studied in rats with lithium-induced polyuria. During a 3-hr period of water deprivation, the rats lost water in amounts corresponding to about 10% of body weight. Lithium clearance fell to about 25% of the level observed in rats which were not water deprived. During shorter periods of water deprivation, the fall of lithium clearance was less. The decrease of lithium clearance was partly due to a fall of inulin clearance and partly due to a fall of fractional excretion of lithium. The decrease of the two variables contributed to the same extent to the decrease of lithium clearance. The findings support the suggestion that insufficient intake of water in patients with lithium-induced polyuria may lead to a rapid lowering of lithium clearance and, hence, to a rise of the serum lithium concentration and development of intoxication.