RT Journal Article
SR Electronic
T1 Dopaminergic control of the septal-hippocampal cholinergic pathway.
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 476
OP 479
VO 208
IS 3
A1 S E Robinson
A1 D Malthe-Sørenssen
A1 P L Wood
A1 J Commissiong
YR 1979
UL http://jpet.aspetjournals.org/content/208/3/476.abstract
AB Apomorphine given subcutaneously is known to decrease the turnover rate of acetylcholine (TR(ACh) in the hippocampus. Blockade of dopaminergic receptors by intraseptal haloperidol or destruction of dopaminergic terminals by intraseptal 6-hydroxydopamine results in an increase in TR(ACh) in the hippocampus. Specific destruction of the dopaminergic neurons projecting to the septum by the injection of 6-hydroxydopamine into the A10 mesencephalic cell group also results in an increased TR(ACh) in the hippocampus. None of the above treatments affects TR(ACh) in the cortex. Thus, it appears that dopaminergic neurons exert a tonic inhibitory effect on the ACh metabolism of the septal-hippocampal pathway, but do not affect that of cholinergic neurons projecting from the septum to the cortex. It can be inferred that this decrease in the rate of metabolism may be associated with a regulation of the rate of neuronal firing.