PT  - JOURNAL ARTICLE
AU  - D B Goldstein
TI  - Sodium bromide and sodium valproate: effective suppressants of ethanol withdrawal reactions in mice.
DP  - 1979 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 223--227
VI  - 208
IP  - 2
4099  - http://jpet.aspetjournals.org/content/208/2/223.short
4100  - http://jpet.aspetjournals.org/content/208/2/223.full
SO  - J Pharmacol Exp Ther1979 Feb 01; 208
AB  - Mice were made physically dependent on ethanol by a 3-day alcohol inhalation regimen, using pyrazole to stabilize blood ethanol concentrations. After withdrawal, convulsions elicited by handling were scored repeatedly for 30 hr as a measure of central nervous system hyperexcitability. Administration of sodium bromide, 0.2 to 2.0 g/kg i.p., suppressed the convulsions in a dose-related fashion. Bromide was effective at subsedative doses. However, bromide increased the postwithdrawal mortality. Bromide may act at chloride channels, as gamma-aminobutyric acid does. Valproate and its amide temporarily suppressed the withdrawal reaction at doses that caused some sedation. Muscimol and beta-alanine had no effect.