RT Journal Article
SR Electronic
T1 The effects of anthopleurin-A on cardiac dynamics in conscious dogs.
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 271
OP 276
VO 207
IS 2
A1 R W Blair
A1 D F Peterson
A1 V S Bishop
YR 1978
UL http://jpet.aspetjournals.org/content/207/2/271.abstract
AB The effects of anthopleurin-A (AP-A), a selective cardiotonic drug, on cardiac dynamics in intact, awake animals were examined. Dogs were instrumented in order to record left ventricular pressure, the derivative of left ventricular pressure (dP/dt), arterial pressure left ventricular end-systolic and end-diastolic diameters, cardiac output, left atrial pressure and heart rate. Left ventricular pressure, dP/dt, stroke volume and cardiac output were significantly increased (16, 46, 37 and 23%, respectively) by AP-A. AP-A significantly diminished heart rate 9 beats/min and left ventricular end-systolic diameter 1.9 mm. Mean arterial pressure, mean left atrial pressure and left ventricular end-diastolic diameter were unaltered by AP-A. Autonomic blockade with atropine and propranolol did not alter these responses on the myocardium qualitatively. Thus, it appears that AP-A has a direct positive inotropic effect on the myocardium in conscious animals with little or no effect on the peripheral circulation.