PT  - JOURNAL ARTICLE
AU  - H E Williamson
AU  - G R Gaffney
AU  - W A Bourland
AU  - D B Farley
AU  - D E Van Orden
TI  - Phenylbutazone-induced decrease in renal blood flow.
DP  - 1978 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 130--134
VI  - 204
IP  - 1
4099  - http://jpet.aspetjournals.org/content/204/1/130.short
4100  - http://jpet.aspetjournals.org/content/204/1/130.full
SO  - J Pharmacol Exp Ther1978 Jan 01; 204
AB  - Phenylbutazone (Butazolidin), and anti-inflammatory agent, has been reported to decrease renal excretion of sodium and water. Whether or not an alteration in renal hemodynamics could be involved in producing these effects was tested in anesthetized dogs. Renal blood flow (RBF) was monitored with electromagnetic flow probes. After i.v. administration of phenylbutazone, 2 mg/kg, RBF fell by 20%. Glomerular filtration rate, sodium and water excretion were also decreased and blood pressure increased slightly. The reduction of RBF and glomerular filtration rate by phenylbutazone indicates that a hemodynamic mechanism could be involved in the retention of sodium and water induced by this agent. The decreased blood flow was correlated with a depressed renal secretion of prostaglandin E. Also, in animals pretreated with indomethacin, another inhibitor of prostaglandin synthesis, administration of phenylbutazone did not result in any additional changes in renal hemodynamics or excretion of sodium and water. In addition, phenylbutazone antagonized the ability of furosemide to increase RBF, an inhibition which has previously been shown to occur with indomethacin. Thus, phenylbutazone appears to alter renal mechanisms in a manner similar to indomethacin.