PT  - JOURNAL ARTICLE
AU  - Dekin, M S
AU  - Guy, H R
AU  - Edwards, C
TI  - Effects of organophosphate insecticides on the cholinergic receptors of frog skeletal muscle.
DP  - 1978 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 319--325
VI  - 205
IP  - 2
4099  - http://jpet.aspetjournals.org/content/205/2/319.short
4100  - http://jpet.aspetjournals.org/content/205/2/319.full
SO  - J Pharmacol Exp Ther1978 May 01; 205
AB  - The organophosphates octamethyl pyrophosphoramide, Bidrin, and phosphoric acid 2,2-dichlorovinyl dimethyl ester inhibit the membrane voltage response of frog sartorius muscles to carbamylcholine in a manner expected of either a slowly reversing competitive inhibitor or a noncompetitive inhibitor. The inhibition reverses with a time course of minutes, depending upon the temperature. The inhibition by these compounds is reduced by d-tubocurarine but is unaffected by hexamethonium. This may indicate that the organophosphate binding sites are near the cholinergic binding site since both d-tubocurarine and hexamethonium are competitive inhibitors of cholinergic agonists and d-tubocurarine is the larger compound.