RT Journal Article
SR Electronic
T1 Adjuvant polyarthritis. II. Suppression by tilorone.
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 156
OP 161
VO 203
IS 1
A1 Chang, Y H
YR 1977
UL http://jpet.aspetjournals.org/content/203/1/156.abstract
AB Tilorone (5-35 mg/kg/day) suppressed the development of adjuvant-induced arthritis and the concurrent development of cell-mediated immune response to a secondary immunogen(EL4 cells) in a dose-related manner. Its influence on the development of the humoral immune response tp EL4 cells was found to be dependent on dosage: stimulatory at low doses (7.5 and 11.0 mg/kg/day), but inhibitory at high doses (24.0 and 35.0 mg/kg/day). Single doses of tilorone (30-300 mg/kg), administered at 24 hours or 1 hour before the injection of carrageenan, suppressed the development of acute inflammation in the rat. Evidence is presented that neither the anti-inflammatory effect of tilorone, nor its influence on the immune response could account for its antiarthritic effect. It appears plausible that the compound may act via interferon induction.