TY - JOUR T1 - Uptake of uric acid by separated renal tubules of the rabbit. II. Effects of drugs. JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 226 LP - 232 VL - 201 IS - 1 AU - I Kippen AU - N Nakata AU - S Honda AU - J R Klinenberg Y1 - 1977/04/01 UR - http://jpet.aspetjournals.org/content/201/1/226.abstract N2 - The effect of various drugs on the rate of uptake of uric acid by separated renal tubules of the rabbit was investigated. Determinations were made of 150 values and slopes of the inhibition curves. The most potent inhibitor of uric acid uptake was sulfinpyrazone, with an 150 of 0.02 mM. Calcium ipodate and benzbromarone were also potent inhibitors. Uricosuric drugs, with the exception of benzbromarone, had shallow inhibition slopes. Diuretic drugs had steep inhibition slopes. More than one mechanism of action is probably involved in the inhibition of uric acid uptake in separated renal tubules by drugs. ER -