PT  - JOURNAL ARTICLE
AU  - Fanelli, G M
AU  - Bohn, D L
AU  - Scriabine, A
AU  - Beyer, K H
TI  - Saluretic and uricosuric effects of (6, 7-dichloro-2-methyl=1-oxo-2-phenyl-5-indanyloxy) acetic acid (MK-196) in the chimpanzee.
DP  - 1977 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 402--412
VI  - 200
IP  - 2
4099  - http://jpet.aspetjournals.org/content/200/2/402.short
4100  - http://jpet.aspetjournals.org/content/200/2/402.full
SO  - J Pharmacol Exp Ther1977 Feb 01; 200
AB  - The saluretic and uricosuric responses elicited by a novel agent, MK-196, have been studied in a great ape, the chimpanzee. This agent is orally active at very low doses and has a prolonged duration of action. Probenecid does not appear to influence the saluretic and uricosuric properties of MK-196. Net tubular secretion of urate was reduced by MK-196. Urinary pH changes did not compromise the efficacy of this new agent. On a dose basis, MK-196 was more saluretic (and uricosuric) than ethacrynic acid or furosemide and possessed a longer duration of action. Because of the marked natriuresis caused by MK-196, some increase in potassium excretion occurred.