PT  - JOURNAL ARTICLE
AU  - J E Byrne
AU  - A W Gomoll
AU  - G R McKinney
TI  - Antiarrhythmic properties of MJ 9067 in acute animal models.
DP  - 1977 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 147--154
VI  - 200
IP  - 1
4099  - http://jpet.aspetjournals.org/content/200/1/147.short
4100  - http://jpet.aspetjournals.org/content/200/1/147.full
SO  - J Pharmacol Exp Ther1977 Jan 01; 200
AB  - A novel benzanilide derivative, MJ 9067, has been shown to abolish experimental atrial and ventricular arrhythmiase effectively and promote the return of normal sinus rhythm in a variety of animal models. At intravenous dose levels ranging from 0.5 to 3.2 mg/kg, MJ 9067 successfully converted atrial fibrillation induced by either local application of aconitine or electrical stimulation, and ventricular tachycardia elicited by intravenous injection of ouabain or digoxin. The compound was equally effective in vagotomized or nonvagotomized dogs, and in intact cats and monkeys. The ventricular ectopic rate in conscious dogs 18 to 20 hours after two-stage ligation of a coronary artery was also markedly reduced by the drug at 2 mg/kg i.v. At antiarrhythmic dose levels, there were no undesirable effects noted on peripheral blood pressure, heart rate or the configuration of the electrocardiogram.