PT  - JOURNAL ARTICLE
AU  - E J Zambraski
AU  - G F Dibona
AU  - G J Kaloyanides
TI  - Effect of sympathetic blocking agents on the antinatriuresis of reflex renal nerve stimulation.
DP  - 1976 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 464--472
VI  - 198
IP  - 2
4099  - http://jpet.aspetjournals.org/content/198/2/464.short
4100  - http://jpet.aspetjournals.org/content/198/2/464.full
SO  - J Pharmacol Exp Ther1976 Aug 01; 198
AB  - To evaluate the effects of reflex renal sympathetic nerve stimulation on renal tubular sodium handling, clearance studies were performed in anesthetized dogs. With renal perfusion pressure held constant, baroreceptor reflex renal sympathetic nerve stimulation was produced by controlled arterial hemorrhage or carotid sinus perfusion. Significant decreases in urinary sodium excretion occurred in the presence of minor insignificant alterations in renal blood flow and no changes in glomerular filtration rate. Renal alpha adrenergic receptor blockade (phenoxybenzamine) or adrenergic blockade (guanethidine) completely reversed the fall in urinary sodium excretion; this could not be attributed to alterations in glomerular filtration rate or renal blood flow. These studies support the interpretation that adrenergic innervation of the renal tubules is involved in the regulation of renal tubular sodium reabsorption.