PT  - JOURNAL ARTICLE
AU  - J W Putney, Jr
TI  - Biphasic modulation of potassium release in rat parotid gland by carbachol and phenylephrine.
DP  - 1976 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 375--384
VI  - 198
IP  - 2
4099  - http://jpet.aspetjournals.org/content/198/2/375.short
4100  - http://jpet.aspetjournals.org/content/198/2/375.full
SO  - J Pharmacol Exp Ther1976 Aug 01; 198
AB  - Both 86Rb and 42K appeared to serve as useful markers for potassium movements in rat parotid gland slices. Carbachol and phenylephrine elicited a biphasic increase in potassium release (86Rb release) that was dose related and could be blocked by atropin and phentolamine, respectively. The early transient phase of 86Rb release lasted from 3 to 6 minutes and was not blocked by removal of external Ca. These observations suggested that the transient phase corresponded to the transient hyperpolarization seen by others in response to alpha adrenergic or cholinergic agents. The latter sustained phase of 86Rb release was qualitatively blocked by chelation of external Ca ions or by 1 mM LaCl3. Thus, the sustained phase of release appeared to relate to the loss of total potassium seen by others with this tissue and to the mechanisms responsible for transporting water from blood to saliva.