RT Journal Article SR Electronic T1 Actions of the antidepressant drug imipramine on the voltage-clamped Myxicola giant axon. JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 669 OP 675 VO 193 IS 2 A1 C L Schauf A1 F A Davis A1 R L Kesler YR 1975 UL http://jpet.aspetjournals.org/content/193/2/669.abstract AB The effects of the antidepressant drug imipramine were studied on the voltage-clamped Myxicola giant axon at concentrations from 10- minus 6 to 5 X 10- minus 5 M. Over this range, imipramine reversibly reduced both the sodium and potassium conductances without having any substantial effect on either the resting membrane potential or the leakage conductance. The observed dose-response relation is described by a Langmuir adsorption isotherm with an apparent dissociation constant of 9 X 10-minus 6 M. The sodium and potassium conductance-voltage curves are shifted in the hyperpolarizing direction along the voltage axis, the magnitude of the displacement increasing with increasing concentrations of imipramine. There was no significant effect of imipramine on either time to peak sodium current or time to half-maximum steady-state current.