RT Journal Article
SR Electronic
T1 Further studies using carbamate esters as model compounds to investigate the role of lipophilicity in the gastrointestinal absorption of foreign compounds.
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 67
OP 72
VO 195
IS 1
A1 J B Houston
A1 D G Upshall
A1 J W Bridges
YR 1975
UL http://jpet.aspetjournals.org/content/195/1/67.abstract
AB In order to examine the validity of models proposed previously for the gastrointestinal absorption of foreign compounds, the absorption behavior of a series of N-methylated carbamates has been studied in the rat. An optimal partition coefficient for the intestinal absorption of these compounds was demonstrated but this value was approximately one order higher than that reported earlier for a related series of unsubstituted carbamates. It is suggested that this difference is due to the modification in hydrogen bonding arising from N-methyl substitution. In contrast, an optimal partition coefficient for gastric absorption could not be demonstrated within the range of the apparent partition coefficient studied. The absorption behavior of the N-methylated carbamates tends to confirm the different trends previously observed between drug absorption from the intestine and that from the stomach.