PT  - JOURNAL ARTICLE
AU  - L C Garg
TI  - The absence of renal bicarbonate reabsorption maxima during carbonic anhydrase inhibition.
DP  - 1975 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 96--102
VI  - 194
IP  - 1
4099  - http://jpet.aspetjournals.org/content/194/1/96.short
4100  - http://jpet.aspetjournals.org/content/194/1/96.full
SO  - J Pharmacol Exp Ther1975 Jul 01; 194
AB  - Present studies were performed to examine the effect of carbonic anhydrase inhibition on bicarbonate reabsorption under experimental conditions where extracellular fluid volume expansion was minimized. The data showed no tubular maximum for bicarbonate reabsorption in the normal state or after carbonic anhydrase inhibition. The data support a model which assumes that the bicarbonate reabsorption is accomplished by two processes. One process is independent of protonation from H+ secretion into the tubule and probably involves reabsorption of bicarbonate ion as such. This process has an unlimited capacity for reabsorption of bicarbonate. The contribution of this process increases with an increase in plasma bicarbonate. The second process is dependent on protonation, through the intracellular hydration of carbon dioxide. The relative contribution, through the intracellular hydration of carbon dioxide. The relative contribution of this process is normally about 33% and decreases with increased plasma bicarbonate.