TY - JOUR T1 - Mechanism of action of colchicine. II. Effects of colchicine and its analogs on phagocytosis and chemotaxis in vitro. JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 159 LP - 164 VL - 194 IS - 1 AU - Y H Chang Y1 - 1975/07/01 UR - http://jpet.aspetjournals.org/content/194/1/159.abstract N2 - Colchicine, desacetylmethylcolchicine and colchiceine suppress the phagocytosis of starch granules by rabbit peritoneal polymorphonuclear leukocytes in vitro. Trimethylcolchicinic acid and 2-desmethylcolchicine glucoside have no effect on phagocytosis. Colchicine, at concentrations as high as 1 X 10(-4) M, has no effect on chemotaxis of polymorphonuclear leukocytes in response to immune complex-activated chemotactic factors or on the motility of these cells. These results do not support the contention that the suppression of phagocytosis or chemotaxis plays a significant role in the anti-inflammatory activity of colchicine. ER -