RT Journal Article
SR Electronic
T1 Pentobarbital pharmacokinetics in the normal and in the hepatectomized rat.
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 111
OP 116
VO 194
IS 1
A1 F W Ossenberg
A1 M Peignoux
A1 D Bourdiau
A1 J P Benhamou
YR 1975
UL http://jpet.aspetjournals.org/content/194/1/111.abstract
AB The pharmacokinetics of pentobarbital, a barbiturate metabolized by the liver, was compared in normal and in hepatectomized rats. The blood concentration time curve following a single intravenous injection of pentobarbital was fitted to a two-compartment open model. Both the volume of the central compartment and the elimination rate constant were significantly reduced in hepatectomized rats. It is concluded that the liver plays a role both in the metabolism and the distribution of pentobarbital.