RT Journal Article
SR Electronic
T1 BIOCHEMICAL PHARMACOLOGY OF THE FIBRINOLYSIN SYSTEM OF THE RAT. III. THE MECHANISM OF PHENFORMIN [1-(β-PHENETHYL)- BIGUANIDE]-INDUCED FIBRINOLYTIC ACTIVITY
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 333
OP 343
VO 189
IS 2
A1 Howard B. Lassman
A1 Nathan Back
YR 1974
UL http://jpet.aspetjournals.org/content/189/2/333.abstract
AB The fibrinolysin system is responsible for the dissolution of blood clots in vivo. Activation of the fibrinolysin system has been achieved by both enzymic and nonenzymic mechanisms. The mechanism of inducing and/or enhancing fibrinolytic activity by phrmacological agents has remained obscure. Phenformin was selected for study since its ability to induce fibrinolytic activity had been previously reported in patients with suppressed fibrinolytic activity. In rats rendered hypofibrinolytic by insulin pretreatment, phenformin produced a significant increase in fibrinolytic potential brought about by activation of plasminogen by an undetectable activator. This was accompanied by a reduction in the acid-labile inhibitors of plasmin and plasminogen activation and an increase in fast and slow antiplasmin levels. Acute administration of phenformin to normal control rats produced an overall suppression of the fibrinolysin system due to increased levels of fast antiplasmin and the acid-labile inhibitors of plasmin. © 1974 by The Williams & Wilkins Co.