RT Journal Article
SR Electronic
T1 The effects of methadone on maternal-fetal interactions in the rat.
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 549
OP 554
VO 192
IS 3
A1 Chandler, J M
A1 Robie, P W
A1 Schoolar, J C
A1 Desmond, M M
YR 1975
UL http://jpet.aspetjournals.org/content/192/3/549.abstract
AB Female Sprague-Dawley rats received methadone (25 mg/kg/day) by gavage throughout gestation. Water-gavaged rats served as controls. Fetuses were delivered by cesarean section when parturition was imminent. Our results indicate that methadone may interfere with fetal development and maternal-fetal interactions to some degree. The observed alterations were as follows: fetal growth retardation, an interference with the triggering of parturition once normal delivery size is attained and possible positional malformations.