PT  - JOURNAL ARTICLE
AU  - J M Chandler
AU  - P W Robie
AU  - J C Schoolar
AU  - M M Desmond
TI  - The effects of methadone on maternal-fetal interactions in the rat.
DP  - 1975 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 549--554
VI  - 192
IP  - 3
4099  - http://jpet.aspetjournals.org/content/192/3/549.short
4100  - http://jpet.aspetjournals.org/content/192/3/549.full
SO  - J Pharmacol Exp Ther1975 Mar 01; 192
AB  - Female Sprague-Dawley rats received methadone (25 mg/kg/day) by gavage throughout gestation. Water-gavaged rats served as controls. Fetuses were delivered by cesarean section when parturition was imminent. Our results indicate that methadone may interfere with fetal development and maternal-fetal interactions to some degree. The observed alterations were as follows: fetal growth retardation, an interference with the triggering of parturition once normal delivery size is attained and possible positional malformations.