RT Journal Article SR Electronic T1 THE ACTION OF DRUGS ON THE OUTPUT OF EPINEPHRIN FROM THE ADRENALS VIII. MORPHINE JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 59 OP 85 VO 19 IS 1 A1 G. N. STEWART A1 J. M. ROGOFF YR 1922 UL http://jpet.aspetjournals.org/content/19/1/59.abstract AB Morphine, administered subcutaneously or intravenously, causes in cats an increase in the rate of output of epinephrin from the adrenals. As much as 10 times the initial rate has been observed. The animals were anesthetised with ether (in one experiment with urethane) before the morphine was administered, and therefore it is not known what increase may be caused in the absence of these anesthetics, which do not themselves appear to increase the output. The symptoms produced by morphine in non-anesthetised cats cannot be due, in any important measure to an increased output of epinephrin, since they are all obtained, and apparently in undiminished intensity, in cats after removal of one adrenal and the chief part of the other, and denervation of the remaining fragment. In dogs either no increase in the output of epinephrin or a very slight one was caused by morphine. This difference in the action of the drug in the two animals is as marked as the other pharmacological differences.