RT Journal Article
SR Electronic
T1 THE IDENTIFICATION OF 2,3-DIHYDROXYBENZOIC ACID AS A POTENTIALLY USEFUL IRON-CHELATING DRUG
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 570
OP 575
VO 190
IS 3
A1 J. H. Graziano
A1 R. W. Grady
A1 A. Cerami
YR 1974
UL http://jpet.aspetjournals.org/content/190/3/570.abstract
AB Using the hypertransfused rat as a model, we have identified 2,3-dihydroxyhenzoic acid (2,3-DHB) as an orally effective iron-chelating agent. The iron excreted in response tc 2,3-DHB is excreted via the urine. The amount of iron excreted is a function of both the dose and time course of the drug administration. The chelation is specific for iron; there were no changes in the amounts of urinary calcium, magnesium, copper or zinc. The oral administration of 2,3-DHB decreased time absorption of iron (59FeCl3,) by the gut even when a physiological amount of iron was added. The LD5O of 2,3-DHB is greater than 3 g/kg in the rabbit. Rats and mice administered up to 600 mg/kg chronically have shown no signs of toxicity. © 1974 by The Williams & Wilkins Co.