PT  - JOURNAL ARTICLE
AU  - J. H. Graziano
AU  - R. W. Grady
AU  - A. Cerami
TI  - THE IDENTIFICATION OF 2,3-DIHYDROXYBENZOIC ACID AS A POTENTIALLY USEFUL IRON-CHELATING DRUG
DP  - 1974 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 570--575
VI  - 190
IP  - 3
4099  - http://jpet.aspetjournals.org/content/190/3/570.short
4100  - http://jpet.aspetjournals.org/content/190/3/570.full
SO  - J Pharmacol Exp Ther1974 Sep 01; 190
AB  - Using the hypertransfused rat as a model, we have identified 2,3-dihydroxyhenzoic acid (2,3-DHB) as an orally effective iron-chelating agent. The iron excreted in response tc 2,3-DHB is excreted via the urine. The amount of iron excreted is a function of both the dose and time course of the drug administration. The chelation is specific for iron; there were no changes in the amounts of urinary calcium, magnesium, copper or zinc. The oral administration of 2,3-DHB decreased time absorption of iron (59FeCl3,) by the gut even when a physiological amount of iron was added. The LD5O of 2,3-DHB is greater than 3 g/kg in the rabbit. Rats and mice administered up to 600 mg/kg chronically have shown no signs of toxicity. © 1974 by The Williams & Wilkins Co.