RT Journal Article
SR Electronic
T1 A COMPARISON OF THE EFFECTS OF <em>d</em>-AMPHETAMINE AND MORPHINE UPON THE LOCOMOTOR ACTIVITY OF MICE TREATED WITH DRUGS WHICH ALTER BRAIN CATECHOLAMINE CONTENT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 1
OP 7
VO 187
IS 1
A1 Villarreal, J. E.
A1 Guzman, M.
A1 Smith, C. B.
YR 1973
UL http://jpet.aspetjournals.org/content/187/1/1.abstract
AB Morphine administration increased markedly the locomotor activity of mice. Pretreatment of mice with reserpine (5 mg/kg i.p., 24 hours) or with α-methyl-p-tyrosine (200 mg/kg i.p., three hours) decreased markedly the activity-increasing effects of morphine. Pretreatment with pargyline (100 mg/kg i.p., three hours) caused a slight shift to the left in the dose-response curve of morphine. In contrast, pretreatment of mice with either reserpine or pargyline caused no significant change in the activity-increasing effects of d-amphetamine. Pretreatment with α-methyl-p-tyrosine caused a shift to the right in the dose-response curve of d-amphetamine but did not decrease the maximum response obtained. The study suggests that certain effects of morphine are mediated by the release of catecholamines from adrenergic neurons in the brain. The present evidence also suggests that the activity-increasing effects of morphine are mediated by mechanisms different from those which mediate the effects of d-amphetamine. © 1973 by The Williams &amp; Wilkins Company