PT - JOURNAL ARTICLE AU - A. J. CLARK TI - THE MODE OF ACTION OF POTASSIUM UPON ISOLATED ORGANS DP - 1921 Dec 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 423--447 VI - 18 IP - 6 4099 - http://jpet.aspetjournals.org/content/18/6/423.short 4100 - http://jpet.aspetjournals.org/content/18/6/423.full SO - J Pharmacol Exp Ther1921 Dec 01; 18 AB - Rubidium acts as a perfect substitute to potassium in all of the isolated tissues examined; caesium acts as an imperfect substitute; thorium and uranium do not act as substitutes to potassium, but they act as irritants to the frog's heart and will induce automatic beats in hearts arrested by lack of potassium. The expenses of this research were defrayed by a grant from the Royal Society.