TY - JOUR T1 - COMPARATIVE STUDY OF THE ACTION OF PHENOTHIAZINE AND <em>para</em>-FLUOROBUTYROPHENONE DERIVATIVES ON RAT BRAIN MEMBRANES USING THE SPIN LABEL TECHNIQUE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 609 LP - 615 VL - 186 IS - 3 AU - F. LETERRIER AU - F. RIEGER AU - J. F. MARIAUD Y1 - 1973/09/01 UR - http://jpet.aspetjournals.org/content/186/3/609.abstract N2 - The spin label technique reveals that phenothiazine and para-fluorobutyrophenone derivatives, such as haloperidol, modify the membrane proteic structure. Both types of drugs give qualitatively similar responses. Phenothiazine derivatives interact with all types of studied membrane material, but only the synaptic fraction is sensitive to the action of para-fluorobutyrophenone compounds. Some correlations can be made between the intensity of the spin label spectroscopic response and the pharmacological activity of the drugs. © 1973 by The Williams &amp; Wilkins Co. ER -