TY - JOUR T1 - EFFECT OF HYCANTHONE AND OF TWO OF ITS STRUCTURAL ANALOGS ON LEVELS AND UPTAKE OF 5-HYDROXYTRYPTAMINE IN <em>SCHISTOSOMA MANSONI</em> JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 408 LP - 415 VL - 186 IS - 3 AU - TSUI-CHIN TSENG CHOU AU - JAMES L. BENNETT AU - CANDACE PERT AU - ERNEST BUEDING Y1 - 1973/09/01 UR - http://jpet.aspetjournals.org/content/186/3/408.abstract N2 - In contrast to other antischistosomal drugs, administration of hycanthone or two of its structural analogs to mice infected with Schistosoma mansoni resulted in an increase in the levels of 5-hydroxytryptamine in the parasites. This effect coincided with a shift of the worms from the mesenteric veins toward the liver and could be accounted for by a stimulation of a low affinity 5-hydroxytryptamine uptake mechanism of schistosomes. Hycanthone treatment of their host resulted in a loss of the ability of the worms to store 5-hydroxytryptamine in neuronal structures, i.e., under these conditions the amine was localized only in extraneuronal tissues. © 1973 by The Williams &amp; Wilkins Co. ER -