RT Journal Article SR Electronic T1 EFFECT OF HYCANTHONE AND OF TWO OF ITS STRUCTURAL ANALOGS ON LEVELS AND UPTAKE OF 5-HYDROXYTRYPTAMINE IN SCHISTOSOMA MANSONI JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 408 OP 415 VO 186 IS 3 A1 TSUI-CHIN TSENG CHOU A1 JAMES L. BENNETT A1 CANDACE PERT A1 ERNEST BUEDING YR 1973 UL http://jpet.aspetjournals.org/content/186/3/408.abstract AB In contrast to other antischistosomal drugs, administration of hycanthone or two of its structural analogs to mice infected with Schistosoma mansoni resulted in an increase in the levels of 5-hydroxytryptamine in the parasites. This effect coincided with a shift of the worms from the mesenteric veins toward the liver and could be accounted for by a stimulation of a low affinity 5-hydroxytryptamine uptake mechanism of schistosomes. Hycanthone treatment of their host resulted in a loss of the ability of the worms to store 5-hydroxytryptamine in neuronal structures, i.e., under these conditions the amine was localized only in extraneuronal tissues. © 1973 by The Williams & Wilkins Co.