RT Journal Article SR Electronic T1 IN VIVO CYTOGENETIC EVALUATION OF CHLOROINDAZOLE THIOXANTHENE IA-4 (A HYCANTHONE ANALOG) AND NIRIDAZOLE IN RAT BONE MARROW JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 399 OP 401 VO 186 IS 3 A1 FRANCES MORELAND SAURO A1 SIDNEY GREEN YR 1973 UL http://jpet.aspetjournals.org/content/186/3/399.abstract AB Niridazole and the hycanthone analog chloroindazole, IA-4, which are members of two different classes of antischistosomal drugs, were evaluated cytogenetically in rat bone marrow cells for mutagenic potential. The hycanthone analog was given to rats i.p. at 50, 100 or 200 mg/kg and the animals were killed 24 hours later. Niridazole was injected i.p. at one dose level (450 mg/kg) and rats were killed 6 or 24 hours postinjection. Treated and control animals were given the mitotic inhibitor demecolcine 4½ hours prior to sacrifice. Slides of bone marrow cells were examined for the presence of chromosome and chromatid damage. Both compounds failed to elicit a statistically significant mutagenic response with regard to the production of grossly visible chromosomal damage. © 1973 by The Williams & Wilkins Co.