RT Journal Article
SR Electronic
T1 AIRWAY CONSTRICTION IN GUINEA PIGS: INTERACTION OF HISTAMINE AND AUTONOMIC DRUGS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 169
OP 179
VO 184
IS 1
A1 J. S. DOUGLAS
A1 M. W. DENNIS
A1 P. RIDGWAY
A1 A. BOUHUYS
YR 1973
UL http://jpet.aspetjournals.org/content/184/1/169.abstract
AB Dose-response curves to i.v. or aerosolized histamine were prepared in 131 guinea pigs using changes of dynamic lung compliance as a measure of response. The ED5O values to aerosolized histamine varied according to a log normal distribution. We modified histamine response with various autonomic drugs. These caused minimal changes of tidal volume, respiratory frequency, minute volume, lung compliance or airway resistance. Atropine and hexamethonium reduced responses to histaimine; physostigmine enhaced them. In urethane-anesthetized aninmals, the protection was reduced and, when hexamethonium was given after urethane, there was a slight potentiation of the histamine response. Guanethidine slightly potentiated bronchoconstriction produced by i.v. and aerosolized histanmine; this potentiation was enhanced by urethane anesthesia. Histamine responses were potentiated by propranolol and dichloroisoproterenol, more so in initially insensitive than in initially sensitive animals. Phentolamine prevented bronchoconstriction in sensitive animals but had little effect in insensitive animals. These results suggest that autonomic mediators interact with histamine in its effect on airway smooth muscle. The individual variability of histamine sensitivity may depend, in part, on the balance between cholinergic and beta adrenergic stimuli which impinge on airway smooth muscle. © 1973 by The Williams & Wilkins Company