PT  - JOURNAL ARTICLE
AU  - BEN G. ZIMMERMAN
TI  - BLOCKADE OF ADRENERGIC POTENTIATING EFFECT OF ANGIOTENSIN BY 1-SAR-8-ALA-ANGIOTENSIN II
DP  - 1973 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 486--492
VI  - 185
IP  - 3
4099  - http://jpet.aspetjournals.org/content/185/3/486.short
4100  - http://jpet.aspetjournals.org/content/185/3/486.full
SO  - J Pharmacol Exp Ther1973 Jun 01; 185
AB  - Responses to adrenergic nerve stimulation and norepinephrine administered i.a. were elicited in the acutely denervated perfused hindpaw of the dog. During the i.a. infusion of 1-Sar-8-Ala-angiotensin II (P-113), 3.2 µg/min, angiotensin II(0.8 µg/min) exerted only a slight vasoconstrictor effect in the paw and failed to potentiate the responses to nerve stimulation or norepinephrine. After allowing approximately 68 minutes for the effect of P-113 to dissipate, angiotensin, 0.8 µg/min, produced potentiation of the responses to nerve stimulation and exogenously administered norepinephrine. The angiotensin blocking agent, P-113, therefore, very effectively interferes with the adrenergic action of angiotensin as well as its direct effect in the hindpaw. The blocking effect of P-113 on the direct vasoconstrictor effect of angiotensin also was examined in the acutely denervated perfused hindlimb muscle of the dog. Administration of P-113 resulted in a 70 to 80% reduction of the vasoconstrictor action of angiotensin in the muscle bed. The results indicate that the antagonist can produce a comparable bockade of the adrenergic and direct vasoconstrictor actions of angiotensin II in the dog when given at 4 times the dose of the agonist. © 1973 by The Williams & Wilkins Co.