RT Journal Article
SR Electronic
T1 ACETYLCHOLINESTERASE INHIBITION AND MORPHINE EFFECTS IN MORPHINE TOLERANT AND DEPENDENT MICE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 31
OP 40
VO 183
IS 1
A1 HEMENDRA N. BHARGAVA
A1 E. LEONG WAY
YR 1972
UL http://jpet.aspetjournals.org/content/183/1/31.abstract
AB Two inhibitors of acetylcholinesterase, physostigmine and diisopropylfluorophosphate, potentiated morphine antinociception, as measured by inhibition of the tail-flick response, in both nontolerant mice and in mice rendered tolerant to morphine by pellet implantation for three days. Although the response to morphine was modified in tolerant animals, inhibition of acetylcholinesterase did not alter the development of tolerance. Physostigmine and diisopropylfluorophosphate also caused pronounced inhibition of naloxone-precipitated withdrawal jumping; however, development of physical dependence on morphine, as measured by body weight loss during abrupt withdrawal, was not affected by the two drugs. These results suggest that some of the actions of morphine might be mediated in part by acetylcholine and, although acetylcholinesterase inhibition may modify the tolerant and dependent state, the mechanism involved primarily in their development is not materially affected. © 1972, by The Williams & Wilkins Company