PT  - JOURNAL ARTICLE
AU  - I. K. HO
AU  - H. H. LOH
AU  - E. LEONG WAY
TI  - EFFECTS OF CYCLIC 3', 5'-ADENOSINE MONOPHOSPHATE ON MORPHINE TOLERANCE AND PHYSICAL DEPENDENCE
DP  - 1973 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 347--357
VI  - 185
IP  - 2
4099  - http://jpet.aspetjournals.org/content/185/2/347.short
4100  - http://jpet.aspetjournals.org/content/185/2/347.full
SO  - J Pharmacol Exp Ther1973 May 01; 185
AB  - The administration of cyclic 3', 5'-adenosine monophosphate (cAMP) antagonized the analgetic response of morphine in both nontolerant and tolerant mice and also accelerated the development of tolerance to and physical dependence on morphine induced by morphine pellet implantation. Tolerance enhancement by cAMP was evidenced by the increased amount of morphine to produce analgesia and acceleration in dependence by the decrease in the amount of naloxone to induce precipitated withdrawal jumping after cAMP pretreatment. Further evidence that cAMP accelerated dependence development on morphine was evidenced by the fact that cAMP increased the loss in body weight that occurred after abrupt morphine withdrawal. Cycloheximide prevented the accelerating effect of cAMP on tolerance and physical dependence development. © 1973 by The Williams & Wilkins Co.