RT Journal Article
SR Electronic
T1 AN ANIMAL MODEL FOR TESTING EFFECTS OF DRUGS ON ALCOHOL WITHDRAWAL REACTIONS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 14
OP 22
VO 183
IS 1
A1 GOLDSTEIN, DORA B.
YR 1972
UL http://jpet.aspetjournals.org/content/183/1/14.abstract
AB Mice were made physically dependent on alcohol by three days of continuous intoxication, produced by inhalation of alcohol vapor. An inhibitor of alcohol metabolism was used to stabilize blood alcohol levels. The severity of the ensuing withdrawal reaction was assessed quantitatively by scoring the intensity of convulsions elicited by lifting the mice. Several drugs suppressed the withdrawal reaction when it was already under way. Effective drugs included ethanol, barbiturates and benzodiazepines. No beneficial effect followed administration of phenothiazines or chlormethiazole. Unexpectedly, some mice died during the withdrawal phase after treatment with long-acting drugs (barbiturates and benzodiazepines) that effectively suppressed the convulsions. © 1972, by The Williams & Wilkins Company