RT Journal Article
SR Electronic
T1 AN INVESTIGATION OF PHARMACOLOGIC AND BEHAVIORAL TOLERANCE TO MORPHINE IN RATS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 300
OP 306
VO 185
IS 2
A1 SABIH KAYAN
A1 R. K. FERGUSON
A1 C. L. MITCHELL
YR 1973
UL http://jpet.aspetjournals.org/content/185/2/300.abstract
AB The effect of experience in the hot-plate procedure on the response to acute and chronic doses of morphine was examined. It was found that a diminution in response to morphine was brought about by the repeated exposure to the test procedure in the absence of drug (initial behavioral tolerance). In addition, there was a diminution in response brought about by an interaction between the exposure to the test procedure and the presence of the drug (chronic behavioral tolerance). Tolerance occurring as a result of the repeated administration of the drug alone also was observed (pharmacologic tolerance). The results also show that 1) the interval between the tests is an important factor in the development of both initial and chronic behavioral tolerance and 2) pharmacologic tolerance develops less rapidly than behavioral tolerance and is influenced both by the frequency of administration and by the magnitude of the dose. © 1973 by The Williams & Wilkins Co.