RT Journal Article
SR Electronic
T1 ENHANCEMENT BY HEMICHOLINIUM-3 OF CHOLINE AND ACETYLCHOLINE EXCRETION BY THE RENAL TUBULE OF THE CHICKEN
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 254
OP 260
VO 185
IS 2
A1 MARGARET ACARA
A1 MARGARET KOWALSKI
A1 BARBARA RENNICK
YR 1973
UL http://jpet.aspetjournals.org/content/185/2/254.abstract
AB The effect of hemicholinium- (HC-3) on the renal tubular transport of the 14C-label associated with choline and acetylcholine was investigated in vivo in the chicken by use of the Sperber technique. It was found that HC-3 given by continuous infusion into the renal portal circulation at rates up to 1 x 10-8 mol/min did not inhibit the transport of either choline or acetylcholine but instead produced an increase in their transport, as indicated by transport efficiency. Choline transport was enhanced about 25% by HC-3 at infusion rates from 1 x 10-22 to 1 x 10-8 mol/min. Acetylcholine transport was enhanced about 19% by HC-3 at 1 x 10-9 mol/min. The unanesthetized chicken could not tolerate HC-3 at infusion rates greater than 1 x 10-7 mol/min. When the administration of HC-3 was stopped, the transport of choline showed a further increase whereas the transport of acetylcholine fell toward control levels. © 1973 by The Williams & Wilkins Co.