%0 Journal Article %A JEROME EDELSON %A J. F. DOUGLAS %T MEASUREMENT OF GASTROINTESTINAL BLOOD LOSS IN THE RAT: THE EFFECT OF ASPIRIN, PHENYLBUTAZONE AND SECLAZONE %D 1973 %J Journal of Pharmacology and Experimental Therapeutics %P 449-452 %V 184 %N 2 %X A practical procedure for the routine measurement of gastrointestinal bleeding in rats was developed. The technique is adapted from the chromium-51-labeled erythrocyte method used in humans. In this modification, we used homologous whole blood instead of autologous red cells. Comparison of several nonsteroidal anti-inflammatory agents tested under these conditions indicated that seclazone did not affect gastrointestinal blood loss whereas phenylbutazone and aspirin both induced gastrointestinal bleeding. © 1973 by The Williams & Wilkins Co. %U https://jpet.aspetjournals.org/content/jpet/184/2/449.full.pdf