RT Journal Article
SR Electronic
T1 PROPRANOLOL METABOLISM IN MAN AND DOG: MASS SPECTROMETRIC IDENTIFICATION OF SIX NEW METABOLITES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 83
OP 92
VO 182
IS 1
A1 THOMAS WALLE
A1 THOMAS E. GAFFNEY
YR 1972
UL http://jpet.aspetjournals.org/content/182/1/83.abstract
AB The metabolism of oral propranolol has been studied in patients and dogs by gas chromatography-mass spectrometry. N-desisopropylpropranolol, 1-(α-naphthoxy)-2,3-propyleneglycol, ring hydroxylated 1-(α-naphthoxy)-2, 3-propyleneglycol, α-naphthoxyacetic acid, α-naphthol and 1,4-dihydroxynaphthalene were identified in urine as were unchanged propranolol and the earlier reported metabolites 4-hydroxypropranolol and naphthoxylactic acid. There were no qualitative differences between the patients and dogs. Several of these metabolites have pharmacological activity which may contribute to the diverse effects of propranolol in man. © 1972, by The Williams & Wilkins Company