PT  - JOURNAL ARTICLE
AU  - D. T. WALZ
AU  - M. J. DiMARTINO
AU  - B. SUTTON
AU  - A. MISHER
TI  - SK&F 36914-AN AGENT FOR ORAL CHRYSOTHERAPY
DP  - 1972 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 292--297
VI  - 181
IP  - 2
4099  - http://jpet.aspetjournals.org/content/181/2/292.short
4100  - http://jpet.aspetjournals.org/content/181/2/292.full
SO  - J Pharmacol Exp Ther1972 May 01; 181
AB  - Chloro (triethylphosphine) gold (SK&F 36914), a new gold compound, administered orally to rats, was equipotent to parenterally administered gold sodium thiomalate in suppressing the development of both the primary and secondary lesions of adjutvantinduced arthritis. Oral absorption of SK&F 36914 was also indicated by the presence of serum gold levels. In contrast, the clinically used gold salt (gold sodium thiomalate) did not produce a therapeutic effect or significant serum gold levels after oral administration to adjuvant arthritic rats. Oral administration of SK&F 36914 produced lower gold levels in both serum and kidneys than equivalent therapeutic doses of parenteral gold sodium thiomalate. Based on these findings, SK&F 36914 would appear to have potential as an agent for oral chrysotherapy. © 1972 by The Williams & Wilkins Co.